Positive tissue transglutaminase antibodies with negative endomysial antibodies: coeliac disease or not?
نویسندگان
چکیده
منابع مشابه
Positive tissue transglutaminase antibodies with negative endomysial antibodies: low rate of celiac disease.
BACKGROUND Screening for celiac disease is based on the sequential evaluation of serologic tests and intestinal biopsy; an optimal screening protocol is still under investigation. The screening policy of one of the main healthcare providers in Israel (Maccabi) consists of measuring total immunoglobulin A and tissue transglutaminase IgA antibodies and confirming positive results by endomysial an...
متن کاملCOELIAC DISEASE Missing endomysial and reticulin binding of coeliac antibodies in transglutaminase 2 knockout tissues
Background: Autoantibodies against transglutaminase 2 (TG2) are thought to be responsible for the endomysial (EMA), reticulin (ARA), and jejunal antibody (JEA) tissue binding of serum samples from coeliac patients but the exclusive role of TG2 in these staining patterns has not yet been established. Aims: To evaluate whether antigens other than TG2 contribute to EMA/ARA/JEA reactions. Patients:...
متن کاملThe Diagnostic Value of Serum IgG-Antigliadin, IgA Anti-endomysial and IgA Anti-tissue Transglutaminase Antibodies for Pediatric Celiac Disease
Background and Objective: Celiac disease is an autoimmune disorder, characterized by inflammation, villous atrophy, and crypt hyperplasia of the small bowel mucosa. In this study we considered and compared sensitivity and specificity of serological tests in patients with celiac disease. Materials and Methods: In this cross-sectional study we prospectively recruited children with suspected c...
متن کاملMissing endomysial and reticulin binding of coeliac antibodies in transglutaminase 2 knockout tissues.
BACKGROUND Autoantibodies against transglutaminase 2 (TG2) are thought to be responsible for the endomysial (EMA), reticulin (ARA), and jejunal antibody (JEA) tissue binding of serum samples from coeliac patients but the exclusive role of TG2 in these staining patterns has not yet been established. AIMS To evaluate whether antigens other than TG2 contribute to EMA/ARA/JEA reactions. PATIENT...
متن کاملCOELIAC DISEASE Anti-tissue transglutaminase antibodies from coeliac patients inhibit transglutaminase activity both in vitro and in situ
Background and aims: Coeliac disease (CD) is a multifactorial disorder which has an autoimmune component characterised by the occurrence of disease specific autoreactive antibodies against the enzyme tissue transglutaminase (tTG). The aim of this study was to investigate whether binding of antibodies to the enzyme influences tTG activity. Methods: tTG activity was assayed in the presence of imm...
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ژورنال
عنوان ژورنال: Frontline Gastroenterology
سال: 2012
ISSN: 2041-4137,2041-4145
DOI: 10.1136/flgastro-2011-100089